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MYL6

CANCER ATLAS

Gene description

 Myosin, light chain 6, alkali, smooth muscle and non-muscle

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046859
HPA063034

GENE INFORMATION

Gene name

 MYL6 (HGNC Symbol)

Synonyms

 ESMLC, MLC1SM, MLC3NM

Description

 Myosin, light chain 6, alkali, smooth muscle and non-muscle (HGNC Symbol)

Entrez gene summary

 Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 56158161 - 56163496

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092841 (version 83.38)

Entrez gene

 4637

UniProt

 P60660 (UniProt - Evidence at protein level)

neXtProt

 NX_P60660

Antibodypedia

 MYL6 antibodies

PROTEIN BROWSER
«
MYL6-001
MYL6-002
MYL6-003
MYL6-005
MYL6-007
MYL6-010
MYL6-013
MYL6-014
MYL6-018
MYL6-022
MYL6-023
MYL6-024
MYL6-025
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL6-001
ENSP00000446687
ENST00000551589
F8W1R7 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 145 aa
16.3 kDa 		No 0
MYL6-002
ENSP00000446714
ENST00000547649
P60660 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007519 [skeletal muscle tissue development]
GO:0008307 [structural constituent of muscle]
GO:0016020 [membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0030049 [muscle filament sliding]
GO:0030898 [actin-dependent ATPase activity]
GO:0031982 [vesicle]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 151 aa
17 kDa 		No 0
MYL6-003
ENSP00000446955
ENST00000550697
P60660 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007519 [skeletal muscle tissue development]
GO:0008307 [structural constituent of muscle]
GO:0016020 [membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0030049 [muscle filament sliding]
GO:0030898 [actin-dependent ATPase activity]
GO:0031982 [vesicle]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 151 aa
16.9 kDa 		No 0
MYL6-005
ENSP00000441750
ENST00000536128
B7Z6Z4 [Direct mapping]
Myosin light polypeptide 6; cDNA FLJ56329, highly similar to Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 238 aa
26.7 kDa 		No 0
MYL6-007
ENSP00000446721
ENST00000547408
G3V1V0 [Direct mapping]
Myosin light polypeptide 6; Myosin, light polypeptide 6, alkali, smooth muscle and non-muscle, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 161 aa
18 kDa 		No 0
MYL6-010
ENSP00000448101
ENST00000548293
P60660 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007519 [skeletal muscle tissue development]
GO:0008307 [structural constituent of muscle]
GO:0016020 [membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0030049 [muscle filament sliding]
GO:0030898 [actin-dependent ATPase activity]
GO:0031982 [vesicle]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 151 aa
16.9 kDa 		No 0
MYL6-013
ENSP00000446709
ENST00000549566
F8W180 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 196 aa
22.1 kDa 		No 0
MYL6-014
ENSP00000446640
ENST00000548580
F8VZU9 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 103 aa
11.7 kDa 		No 0
MYL6-018
ENSP00000448859
ENST00000548400
G3V1Y7 [Direct mapping]
Myosin light polypeptide 6; Myosin, light polypeptide 6, alkali, smooth muscle and non-muscle, isoform CRA_d
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 115 aa
13.2 kDa 		No 0
MYL6-022
ENSP00000450116
ENST00000549392
F8VPF3 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 130 aa
14.4 kDa 		No 0
MYL6-023
ENSP00000293422
ENST00000293422
G8JLA2 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 152 aa
17.1 kDa 		No 0
MYL6-024
ENSP00000301540
ENST00000348108
J3KND3 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 152 aa
17.1 kDa 		No 0
MYL6-025
ENSP00000449086
ENST00000549017
F8VXL3 [Direct mapping]
Myosin light polypeptide 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 47 aa
5.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.