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DPYSL2

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GENERAL INFORMATION

Gene name

 DPYSL2

Gene description

 Dihydropyrimidinase-like 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA002381
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

 Cytosol (supported)

Additional location

 Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA002381 A-431 Cytosol
HPA002381 U-2 OS Plasma membrane
Cytosol
HPA002381 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 DPYSL2 (HGNC Symbol)

Synonyms

 CRMP2, DHPRP2, DRP-2, DRP2

Description

 Dihydropyrimidinase-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 8

Cytoband

 p21.2

Chromosome location (bp)

 26514275 - 26658178

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092964 (version 83.38)

Entrez gene

 1808

UniProt

 Q16555 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16555

Antibodypedia

 DPYSL2 antibodies

PROTEIN BROWSER
DPYSL2-001
DPYSL2-002
DPYSL2-005
DPYSL2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPYSL2-001
ENSP00000309539
ENST00000311151
Q16555 [Direct mapping]
Dihydropyrimidinase-related protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001975 [response to amphetamine]
GO:0004157 [dihydropyrimidinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006897 [endocytosis]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0008017 [microtubule binding]
GO:0010975 [regulation of neuron projection development]
GO:0014049 [positive regulation of glutamate secretion]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0019901 [protein kinase binding]
GO:0021510 [spinal cord development]
GO:0021772 [olfactory bulb development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0045664 [regulation of neuron differentiation]
GO:0048489 [synaptic vesicle transport]
GO:0070062 [extracellular exosome]
Show all
 572 aa
62.3 kDa 		No 0
DPYSL2-002
ENSP00000431117
ENST00000523027
Q16555 [Direct mapping]
Dihydropyrimidinase-related protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004157 [dihydropyrimidinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006897 [endocytosis]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0030516 [regulation of axon extension]
GO:0070062 [extracellular exosome]
Show all
 536 aa
58.2 kDa 		No 0
DPYSL2-005
ENSP00000427985
ENST00000521913
Q16555 [Direct mapping]
Dihydropyrimidinase-related protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004157 [dihydropyrimidinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006897 [endocytosis]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0030516 [regulation of axon extension]
GO:0070062 [extracellular exosome]
Show all
 536 aa
58.2 kDa 		No 0
DPYSL2-007
ENSP00000427954
ENST00000493789
E5RFU4 [Direct mapping]
Dihydropyrimidinase-related protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0030516 [regulation of axon extension]
Show all
 170 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.