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CDC45

GENERAL INFORMATION

Gene name

 CDC45

Gene description

 Cell division cycle 45

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Group enriched (testis, tonsil, appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues, most abundant in testicular seminiferous duct.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000614 , CAB009459
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, tonsil, appendix)

GENE INFORMATION

Gene name

 CDC45 (HGNC Symbol)

Synonyms

 CDC45L, CDC45L2

Description

 Cell division cycle 45 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 19479459 - 19520612

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000093009 (version 83.38)

Entrez gene

 8318

UniProt

 O75419 (UniProt - Evidence at protein level)

neXtProt

 NX_O75419

Antibodypedia

 CDC45 antibodies

PROTEIN BROWSER
CDC45-001
CDC45-002
CDC45-003
CDC45-004
CDC45-201
CDC45-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC45-001
ENSP00000385240
ENST00000407835
O75419 [Direct mapping]
Cell division control protein 45 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000076 [DNA replication checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005656 [nuclear pre-replicative complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006267 [pre-replicative complex assembly involved in nuclear cell cycle DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031261 [DNA replication preinitiation complex]
GO:0031298 [replication fork protection complex]
GO:0031938 [regulation of chromatin silencing at telomere]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902977 [mitotic DNA replication preinitiation complex assembly]
Show all
 566 aa
65.6 kDa 		No 0
CDC45-002
ENSP00000384978
ENST00000404724
O75419 [Direct mapping]
Cell division control protein 45 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000076 [DNA replication checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005656 [nuclear pre-replicative complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006267 [pre-replicative complex assembly involved in nuclear cell cycle DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031261 [DNA replication preinitiation complex]
GO:0031298 [replication fork protection complex]
GO:0031938 [regulation of chromatin silencing at telomere]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902977 [mitotic DNA replication preinitiation complex assembly]
Show all
 520 aa
60.2 kDa 		No 0
CDC45-003
ENSP00000397434
ENST00000438587
C9J911 [Direct mapping]
Cell division control protein 45 homolog
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000727 [double-strand break repair via break-induced replication]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005656 [nuclear pre-replicative complex]
GO:0005813 [centrosome]
GO:0006267 [pre-replicative complex assembly involved in nuclear cell cycle DNA replication]
GO:0006270 [DNA replication initiation]
GO:0031261 [DNA replication preinitiation complex]
GO:0031298 [replication fork protection complex]
GO:0031938 [regulation of chromatin silencing at telomere]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902977 [mitotic DNA replication preinitiation complex assembly]
Show all
 159 aa
18.5 kDa 		Yes 0
CDC45-004
ENSP00000413138
ENST00000455750
C9K087 [Direct mapping]
Cell division control protein 45 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000727 [double-strand break repair via break-induced replication]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0005656 [nuclear pre-replicative complex]
GO:0006267 [pre-replicative complex assembly involved in nuclear cell cycle DNA replication]
GO:0006270 [DNA replication initiation]
GO:0031261 [DNA replication preinitiation complex]
GO:0031298 [replication fork protection complex]
GO:0031938 [regulation of chromatin silencing at telomere]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902977 [mitotic DNA replication preinitiation complex assembly]
Show all
 112 aa
13 kDa 		No 0
CDC45-201
ENSP00000263201
ENST00000263201
O75419 [Direct mapping]
Cell division control protein 45 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000076 [DNA replication checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005656 [nuclear pre-replicative complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006267 [pre-replicative complex assembly involved in nuclear cell cycle DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031261 [DNA replication preinitiation complex]
GO:0031298 [replication fork protection complex]
GO:0031938 [regulation of chromatin silencing at telomere]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902977 [mitotic DNA replication preinitiation complex assembly]
Show all
 566 aa
65.6 kDa 		No 0
CDC45-202
ENSP00000405726
ENST00000437685
O75419 [Direct mapping]
Cell division control protein 45 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000076 [DNA replication checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005656 [nuclear pre-replicative complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006267 [pre-replicative complex assembly involved in nuclear cell cycle DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031261 [DNA replication preinitiation complex]
GO:0031298 [replication fork protection complex]
GO:0031938 [regulation of chromatin silencing at telomere]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902977 [mitotic DNA replication preinitiation complex assembly]
Show all
 598 aa
68.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.