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Cytoplasmic and nuclear expression in most tissues.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Cilia staining is viewed as off target binding and disregarded.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Q9UJX2 [Direct mapping] Cell division cycle protein 23 homolog
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Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0007080 [mitotic metaphase plate congression] GO:0007091 [metaphase/anaphase transition of mitotic cell cycle] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007096 [regulation of exit from mitosis] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination]
