Tissue expression of FMO2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FMO2
Gene description	Flavin containing monooxygenase 2 (non-functional)
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung, esophagus, adipose tissue)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA028261
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, esophagus, adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	FMO2
Synonyms
Description	Flavin containing monooxygenase 2 (non-functional) (HGNC Symbol)
Entrez gene summary	This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Chromosome	1
Cytoband	q24.3
Chromosome location (bp)	171185208 - 171211230
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000094963 (version 83.38)
Entrez gene	2327
UniProt	Q99518 (UniProt - Evidence at protein level)
neXtProt	NX_Q99518
Antibodypedia	FMO2 antibodies

PROTEIN BROWSER

FMO2-001	FMO2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FMO2-001 ENSP00000209929 ENST00000209929	Q99518 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004497 [monooxygenase activity] GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006082 [organic acid metabolic process] GO:0006739 [NADP metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009404 [toxin metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0070995 [NADPH oxidation] GO:0072592 [oxygen metabolic process] Show all	535 aa 60.9 kDa	Yes	1
FMO2-006 ENSP00000487216 ENST00000483192	A0A0D9SG76 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	131 aa 14.8 kDa	Yes	0