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Most cancer tissues showed moderate cytoplasmic positivity. Additional staining of luminal membranes was observed in adenocarcinomas. Colorectal cancers were in general strongly stained.
Moderate to strong membranous and cytoplasmic positivity was observed in gastric cancers. Cases of moderate immunoreactivity was observed in malignant melanoma, colorectal, ovarian, cervical, pancreatic and liver cancers. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
DHPS (HGNC Symbol)
Synonyms
MIG13
Description
Deoxyhypusine synthase (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006412 [translation] GO:0008284 [positive regulation of cell proliferation] GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine] GO:0034038 [deoxyhypusine synthase activity] GO:0042102 [positive regulation of T cell proliferation] GO:0042593 [glucose homeostasis] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050983 [deoxyhypusine biosynthetic process from spermidine] GO:0051289 [protein homotetramerization]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006412 [translation] GO:0008284 [positive regulation of cell proliferation] GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine] GO:0034038 [deoxyhypusine synthase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050983 [deoxyhypusine biosynthetic process from spermidine]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006412 [translation] GO:0008284 [positive regulation of cell proliferation] GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine] GO:0034038 [deoxyhypusine synthase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050983 [deoxyhypusine biosynthetic process from spermidine]
