Cell atlas - BTAF1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

BTAF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	BTAF1
Gene description	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA070682
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (supported), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070682	HaCaT	Nucleoplasm
	HPA070682	HaCaT	Vesicles
	HPA070682	HeLa	Nucleoplasm
	HPA070682	HeLa	Vesicles
	HPA070682	U-2 OS	Nucleoplasm
	HPA070682	U-2 OS	Vesicles

GENE INFORMATION
Gene name	BTAF1 (HGNC Symbol)
Synonyms	MOT1, TAF(II)170, TAF-172, TAF172, TAFII170
Description	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Chromosome	10
Cytoband	q23.32
Chromosome location (bp)	91923769 - 92030325
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095564 (version 83.38)
Entrez gene	9044
UniProt	O14981 (UniProt - Evidence at protein level)
neXtProt	NX_O14981
Antibodypedia	BTAF1 antibodies

PROTEIN BROWSER

BTAF1-001	BTAF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTAF1-001 ENSP00000265990 ENST00000265990	O14981 [Direct mapping] TATA-binding protein-associated factor 172 Q2M1V9 [Target identity:100%; Query identity:100%] BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa; BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004386 [helicase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0035562 [negative regulation of chromatin binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	1849 aa 206.9 kDa	No	0
BTAF1-201 ENSP00000439924 ENST00000544642	A0A0A0MTH9 [Direct mapping] TATA-binding protein-associated factor 172 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005524 [ATP binding] Show all	1849 aa 206.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.