Tissue expression of CYP26A1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CYP26A1
Gene description	Cytochrome P450, family 26, subfamily A, polypeptide 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Group enriched (retina, liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (retina, liver)

GENE INFORMATION
Gene name	CYP26A1 (HGNC Symbol)
Synonyms	CP26, CYP26, P450RAI, P450RAI1
Description	Cytochrome P450, family 26, subfamily A, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q23.33
Chromosome location (bp)	93073475 - 93077890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095596 (version 83.38)
Entrez gene	1592
UniProt	O43174 (UniProt - Evidence at transcript level)
neXtProt	NX_O43174
Antibodypedia	CYP26A1 antibodies

PROTEIN BROWSER

CYP26A1-001	CYP26A1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP26A1-001 ENSP00000360586 ENST00000371531	O43174 [Direct mapping] Cytochrome P450 26A1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001972 [retinoic acid binding] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006766 [vitamin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008401 [retinoic acid 4-hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0034653 [retinoic acid catabolic process] GO:0044281 [small molecule metabolic process] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0055114 [oxidation-reduction process] Show all	428 aa 48.6 kDa	No	0
CYP26A1-002 ENSP00000224356 ENST00000224356	O43174 [Direct mapping] Cytochrome P450 26A1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001972 [retinoic acid binding] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006766 [vitamin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008401 [retinoic acid 4-hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0034653 [retinoic acid catabolic process] GO:0044281 [small molecule metabolic process] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0055114 [oxidation-reduction process] Show all	497 aa 56.2 kDa	No	0