Expression of CRTAC1 in cancer - Summary

CANCER ATLAS

Gene description

Cartilage acidic protein 1

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008175

GENE INFORMATION
Gene name	CRTAC1 (HGNC Symbol)
Synonyms	ASPIC1, CEP-68, FLJ10320
Description	Cartilage acidic protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	10
Cytoband	q24.2
Chromosome location (bp)	97865000 - 98030828
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095713 (version 83.38)
Entrez gene	55118
UniProt	Q9NQ79 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQ79
Antibodypedia	CRTAC1 antibodies

PROTEIN BROWSER

CRTAC1-001	CRTAC1-002	CRTAC1-003	CRTAC1-004	CRTAC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRTAC1-001 ENSP00000359629 ENST00000370597	Q9NQ79 [Direct mapping] Cartilage acidic protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007413 [axonal fasciculation] GO:0021772 [olfactory bulb development] GO:0030426 [growth cone] GO:0070062 [extracellular exosome] GO:1900121 [negative regulation of receptor binding] Show all	661 aa 71.4 kDa	Yes	0
CRTAC1-002 ENSP00000408445 ENST00000413387	Q5T4F6 [Direct mapping] Cartilage acidic protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		524 aa 56.6 kDa	No	0
CRTAC1-003 ENSP00000310810 ENST00000309155	A0A0C4DFP6 [Direct mapping] Cartilage acidic protein 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	637 aa 69.7 kDa	Yes	0
CRTAC1-004 ENSP00000404549 ENST00000436034	H0Y6C6 [Direct mapping] Cartilage acidic protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.2 kDa	No	0
CRTAC1-201 ENSP00000359623 ENST00000370591	Q9NQ79 [Direct mapping] Cartilage acidic protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0070062 [extracellular exosome] Show all	645 aa 70.4 kDa	Yes	0