Tissue expression of WAC - Summary - The Human Protein Atlas

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WAC

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	WAC
Gene description	WW domain containing adaptor with coiled-coil
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036528
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	WAC (HGNC Symbol)
Synonyms	BM-016, FLJ31290, MGC10753, PRO1741, Wwp4
Description	WW domain containing adaptor with coiled-coil (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Chromosome	10
Cytoband	p12.1
Chromosome location (bp)	28532493 - 28623112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095787 (version 83.38)
Entrez gene	51322
UniProt	Q9BTA9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTA9
Antibodypedia	WAC antibodies

PROTEIN BROWSER

WAC-001	WAC-004	WAC-006	WAC-009	WAC-010	WAC-012	WAC-016	WAC-017	WAC-024	WAC-201	WAC-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WAC-001 ENSP00000364797 ENST00000375646	A0A0A0MRT2 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	495 aa 53.9 kDa	No	0
WAC-004 ENSP00000404758 ENST00000420266	C9JD58 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	204 aa 23.1 kDa	No	0
WAC-006 ENSP00000311106 ENST00000347934	Q9BTA9 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0010390 [histone monoubiquitination] GO:0016239 [positive regulation of macroautophagy] GO:0016607 [nuclear speck] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0044783 [G1 DNA damage checkpoint] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0071894 [histone H2B conserved C-terminal lysine ubiquitination] Show all	544 aa 59.5 kDa	No	0
WAC-009 ENSP00000395008 ENST00000448193	C9JMU2 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.7 kDa	No	0
WAC-010 ENSP00000400848 ENST00000442148	C9JVK6 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	173 aa 19.6 kDa	No	0
WAC-012 ENSP00000415645 ENST00000414108	J3QTA0 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	233 aa 26.3 kDa	No	0
WAC-016 ENSP00000364816 ENST00000375664	Q9BTA9 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0010390 [histone monoubiquitination] GO:0016239 [positive regulation of macroautophagy] GO:0016607 [nuclear speck] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0044783 [G1 DNA damage checkpoint] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0071894 [histone H2B conserved C-terminal lysine ubiquitination] Show all	602 aa 65.5 kDa	No	0
WAC-017 ENSP00000346986 ENST00000354911	Q9BTA9 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0010390 [histone monoubiquitination] GO:0016239 [positive regulation of macroautophagy] GO:0016607 [nuclear speck] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0044783 [G1 DNA damage checkpoint] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0071894 [histone H2B conserved C-terminal lysine ubiquitination] Show all	647 aa 70.7 kDa	No	0
WAC-024 ENSP00000434903 ENST00000526722	E9PMZ7 [Direct mapping] WW domain-containing adapter protein with coiled-coil Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4 kDa	No	0
WAC-201 ENSP00000399706 ENST00000428935	Q9P1G8 [Direct mapping] PRO1741; WW domain-containing adapter protein with coiled-coil Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.8 kDa	No	2
WAC-202 ENSP00000486994 ENST00000628285	Q9P1G8 [Direct mapping] PRO1741; WW domain-containing adapter protein with coiled-coil Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.8 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
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