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HSP90AB1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HSP90AB1

Gene description

Heat shock protein 90kDa alpha (cytosolic), class B member 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB005230
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
N/A
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
N/ACerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin02004006008001,0001,2001,400TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0200400600800RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05001,0001,5002,0002,5003,000Tags Per Million

GENE INFORMATION

Gene name

HSP90AB1 (HGNC Symbol)

Synonyms

HSPC2, HSPCB

Description

Heat shock protein 90kDa alpha (cytosolic), class B member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

44246166 - 44253888

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000096384 (version 83.38)

Entrez gene

3326

UniProt

P08238 (UniProt - Evidence at protein level)

neXtProt

NX_P08238

Antibodypedia

HSP90AB1 antibodies

PROTEIN BROWSER

HSP90AB1-003
HSP90AB1-004
HSP90AB1-005
HSP90AB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSP90AB1-003
ENSP00000360709
ENST00000371646
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0016020 [membrane]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
724 aa
83.3 kDa
No 0
HSP90AB1-004
ENSP00000325875
ENST00000353801
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0016020 [membrane]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
724 aa
83.3 kDa
No 0
HSP90AB1-005
ENSP00000360609
ENST00000371554
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001890 [placenta development]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017098 [sulfonylurea receptor binding]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031526 [brush border membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032564 [dATP binding]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045793 [positive regulation of cell size]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071353 [cellular response to interleukin-4]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
724 aa
83.3 kDa
No 0
HSP90AB1-201
ENSP00000481908
ENST00000620073
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0016020 [membrane]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
724 aa
83.3 kDa
No 0

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