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Testicular and urothelial cancers showed strong immunoreactivity. Renal cancers were weakly stained or negative. Remaining malignancies showed weak to moderate nuclear positivity.
GENE INFORMATION
Gene name
CDC5L (HGNC Symbol)
Synonyms
CDC5, CEF1, hCDC5, PCDC5RP
Description
Cell division cycle 5-like (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Q99459 [Direct mapping] Cell division cycle 5-like protein
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Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)