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Most cancer tissues showed moderate to strong cytoplasmic positivity. Gliomas, lymphomas, testis and prostate cancers were mainly weakly stained or negative.
GENE INFORMATION
Gene name
ITPR3 (HGNC Symbol)
Synonyms
IP3R3
Description
Inositol 1,4,5-trisphosphate receptor, type 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]