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Cancer tissues displayed weak to moderate cytoplasmic and or nuclear positivity. Membranous staining was observed in colorectal cancers. Few cases of testicular cancers were strongly stained. Several cases of lymphomas, lung, skin and cervical cancers were negative.
Tumour tissues showed weak to moderate cytoplasmic staining. Lymphomas showed strong staining in most cases. Single cases of prostate, ovarian, cervical and liver cancers were also strongly stained. Most cases of gliomas, skin cancers and renal cancers were negative. Other malignancies were weakly to moderately stained.
GENE INFORMATION
Gene name
JAK2 (HGNC Symbol)
Synonyms
JTK10
Description
Janus kinase 2 (HGNC Symbol)
Entrez gene summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0002250 [adaptive immune response] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005131 [growth hormone receptor binding] GO:0005143 [interleukin-12 receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005901 [caveola] GO:0006325 [chromatin organization] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006928 [movement of cell or subcellular component] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007259 [JAK-STAT cascade] GO:0007260 [tyrosine phosphorylation of STAT protein] GO:0007262 [STAT protein import into nucleus] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007498 [mesoderm development] GO:0007596 [blood coagulation] GO:0008022 [protein C-terminus binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0009755 [hormone-mediated signaling pathway] GO:0010667 [negative regulation of cardiac muscle cell apoptotic process] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0020037 [heme binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030041 [actin filament polymerization] GO:0030099 [myeloid cell differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030335 [positive regulation of cell migration] GO:0031103 [axon regeneration] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031702 [type 1 angiotensin receptor binding] GO:0031904 [endosome lumen] GO:0031959 [mineralocorticoid receptor signaling pathway] GO:0032024 [positive regulation of insulin secretion] GO:0032496 [response to lipopolysaccharide] GO:0032516 [positive regulation of phosphoprotein phosphatase activity] GO:0032731 [positive regulation of interleukin-1 beta production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0033130 [acetylcholine receptor binding] GO:0033160 [positive regulation of protein import into nucleus, translocation] GO:0033194 [response to hydroperoxide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034050 [host programmed cell death induced by symbiont] GO:0034612 [response to tumor necrosis factor] GO:0035401 [histone kinase activity (H3-Y41 specific)] GO:0035409 [histone H3-Y41 phosphorylation] GO:0035556 [intracellular signal transduction] GO:0035722 [interleukin-12-mediated signaling pathway] GO:0036016 [cellular response to interleukin-3] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0042393 [histone binding] GO:0042503 [tyrosine phosphorylation of Stat3 protein] GO:0042506 [tyrosine phosphorylation of Stat5 protein] GO:0042508 [tyrosine phosphorylation of Stat1 protein] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein] GO:0042977 [activation of JAK2 kinase activity] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043392 [negative regulation of DNA binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043560 [insulin receptor substrate binding] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045597 [positive regulation of cell differentiation] GO:0045822 [negative regulation of heart contraction] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046677 [response to antibiotic] GO:0046777 [protein autophosphorylation] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050867 [positive regulation of cell activation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051428 [peptide hormone receptor binding] GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061180 [mammary gland epithelium development] GO:0070671 [response to interleukin-12] GO:0071222 [cellular response to lipopolysaccharide] GO:0071549 [cellular response to dexamethasone stimulus] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:2001235 [positive regulation of apoptotic signaling pathway]