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CDC7

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GENERAL INFORMATION

Gene name

 CDC7

Gene description

 Cell division cycle 7

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge & mitotic spindle.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytokinetic bridge (supported), Mitotic spindle (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA035831
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge & mitotic spindle.

Main location

 Nucleoplasm (supported)

Additional location

 Cytokinetic bridge (supported), Mitotic spindle (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035831 A-431 Nucleoplasm Intensity
HPA035831 U-2 OS Nucleoplasm Intensity
HPA035831 U-251 MG Nucleoplasm Intensity
Cytokinetic bridge Intensity Intensity
Mitotic spindle Intensity Intensity

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Cytokinetic bridge, Mitotic spindle, Nucleoplasm

GENE INFORMATION

Gene name

 CDC7 (HGNC Symbol)

Synonyms

 CDC7L1, HsCdc7, Hsk1, huCdc7

Description

 Cell division cycle 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 91500893 - 91525764

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000097046 (version 83.38)

Entrez gene

 8317

UniProt

 O00311 (UniProt - Evidence at protein level)

neXtProt

 NX_O00311

Antibodypedia

 CDC7 antibodies

PROTEIN BROWSER
CDC7-001
CDC7-002
CDC7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC7-001
ENSP00000234626
ENST00000234626
O00311 [Direct mapping]
Cell division cycle 7-related protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010571 [positive regulation of nuclear cell cycle DNA replication]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0044770 [cell cycle phase transition]
GO:0045171 [intercellular bridge]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 574 aa
63.9 kDa 		No 0
CDC7-002
ENSP00000398077
ENST00000426137
B1AMW7 [Direct mapping]
Cell division cycle 7-related protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000727 [double-strand break repair via break-induced replication]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006270 [DNA replication initiation]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0008360 [regulation of cell shape]
GO:0015630 [microtubule cytoskeleton]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0045171 [intercellular bridge]
Show all
 157 aa
17.7 kDa 		No 0
CDC7-201
ENSP00000393139
ENST00000428239
O00311 [Direct mapping]
Cell division cycle 7-related protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010571 [positive regulation of nuclear cell cycle DNA replication]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0044770 [cell cycle phase transition]
GO:0045171 [intercellular bridge]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 574 aa
63.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.