Cell atlas - PCSK5 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PCSK5

premium

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PCSK5
Gene description	Proprotein convertase subtilisin/kexin type 5
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (U-2 OS, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA031072
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031072	CACO-2	Golgi apparatus
	HPA031072	RH-30	Golgi apparatus
	HPA031072	U-2 OS	Golgi apparatus

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA031072	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. PCSK5 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	PCSK5 (HGNC Symbol)
Synonyms	PC5, PC6, SPC6
Description	Proprotein convertase subtilisin/kexin type 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	75890644 - 76362339
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099139 (version 83.38)
Entrez gene	5125
UniProt	Q92824 (UniProt - Evidence at protein level)
neXtProt	NX_Q92824
Antibodypedia	PCSK5 antibodies

PROTEIN BROWSER

PCSK5-001	PCSK5-002	PCSK5-003	PCSK5-004	PCSK5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCSK5-001 ENSP00000365943 ENST00000376752	Q92824 [Direct mapping] Proprotein convertase subtilisin/kexin type 5 Show all	Enzymes Peptidases Serine-type peptidases THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002001 [renin secretion into blood stream] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005796 [Golgi lumen] GO:0006465 [signal peptide processing] GO:0006508 [proteolysis] GO:0007267 [cell-cell signaling] GO:0007507 [heart development] GO:0007566 [embryo implantation] GO:0008233 [peptidase activity] GO:0009952 [anterior/posterior pattern specification] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0019058 [viral life cycle] GO:0030141 [secretory granule] GO:0030323 [respiratory tube development] GO:0032455 [nerve growth factor processing] GO:0035108 [limb morphogenesis] GO:0042089 [cytokine biosynthetic process] GO:0042277 [peptide binding] GO:0043043 [peptide biosynthetic process] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048566 [embryonic digestive tract development] GO:0048706 [embryonic skeletal system development] Show all	913 aa 101.6 kDa	Yes	0
PCSK5-002 ENSP00000411654 ENST00000424854	Q5JSG7 [Direct mapping] Proprotein convertase subtilisin/kexin type 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	1560 aa 173.9 kDa	No	1
PCSK5-003 ENSP00000365958 ENST00000376767	B1AMG5 [Direct mapping] Proprotein convertase subtilisin/kexin type 5 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] Show all	690 aa 77.7 kDa	Yes	0
PCSK5-004 ENSP00000407239 ENST00000455778	B1AMG8 [Direct mapping] Proprotein convertase subtilisin/kexin type 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	101 aa 10.8 kDa	No	0
PCSK5-201 ENSP00000446280 ENST00000545128	Q92824 [Direct mapping] Proprotein convertase subtilisin/kexin type 5 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002001 [renin secretion into blood stream] GO:0003279 [cardiac septum development] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005796 [Golgi lumen] GO:0006465 [signal peptide processing] GO:0006508 [proteolysis] GO:0007267 [cell-cell signaling] GO:0007368 [determination of left/right symmetry] GO:0007507 [heart development] GO:0007566 [embryo implantation] GO:0008233 [peptidase activity] GO:0009952 [anterior/posterior pattern specification] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0019058 [viral life cycle] GO:0030141 [secretory granule] GO:0030323 [respiratory tube development] GO:0032455 [nerve growth factor processing] GO:0035108 [limb morphogenesis] GO:0042089 [cytokine biosynthetic process] GO:0042277 [peptide binding] GO:0043043 [peptide biosynthetic process] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048566 [embryonic digestive tract development] GO:0048706 [embryonic skeletal system development] GO:0060976 [coronary vasculature development] Show all	1860 aa 206.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.