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TMED1

GENERAL INFORMATION

Gene name

 TMED1

Gene description

 Transmembrane p24 trafficking protein 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA018507
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TMED1 (HGNC Symbol)

Synonyms

 Il1rl1l, IL1RL1LG, MGC1270, p24g1, p24gamma1, ST2L

Description

 Transmembrane p24 trafficking protein 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10832438 - 10836318

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099203 (version 83.38)

Entrez gene

 11018

UniProt

 Q13445 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13445

Antibodypedia

 TMED1 antibodies

PROTEIN BROWSER
TMED1-001
TMED1-003
TMED1-004
TMED1-006
TMED1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TMED1-001
ENSP00000214869
ENST00000214869
Q13445 [Direct mapping]
Transmembrane emp24 domain-containing protein 1
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Show all
 227 aa
25.2 kDa 		Yes 1
TMED1-003
ENSP00000464824
ENST00000588289
K7EIN4 [Direct mapping]
Transmembrane emp24 domain-containing protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
Show all
 82 aa
9.6 kDa 		No 1
TMED1-004
ENSP00000464856
ENST00000586835
K7EIR1 [Direct mapping]
Transmembrane emp24 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 65 aa
7 kDa 		No 0
TMED1-006
ENSP00000468294
ENST00000591695
K7ERK5 [Direct mapping]
Transmembrane emp24 domain-containing protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
Show all
 185 aa
19.6 kDa 		Yes 0
TMED1-007
ENSP00000467690
ENST00000589638
K7EQ63 [Direct mapping]
Transmembrane emp24 domain-containing protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
Show all
 191 aa
21 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.