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RAB18

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GENERAL INFORMATION

Gene name

 RAB18

Gene description

 RAB18, member RAS oncogene family

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 RAB18

Synonyms

Description

 RAB18, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 27504174 - 27542237

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099246 (version 83.38)

Entrez gene

 22931

UniProt

 Q9NP72 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP72

Antibodypedia

 RAB18 antibodies

PROTEIN BROWSER
RAB18-001
RAB18-003
RAB18-005
RAB18-201
RAB18-202
RAB18-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB18-001
ENSP00000349415
ENST00000356940
Q9NP72 [Direct mapping]
Ras-related protein Rab-18
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001654 [eye development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0032482 [Rab protein signal transduction]
GO:0034389 [lipid particle organization]
GO:0070062 [extracellular exosome]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0071786 [endoplasmic reticulum tubular network organization]
Show all
 206 aa
23 kDa 		No 0
RAB18-003
ENSP00000364960
ENST00000375802
Q5W0J0 [Direct mapping]
Ras-related protein Rab-18
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 161 aa
18 kDa 		No 0
RAB18-005
ENSP00000407872
ENST00000423465
H0Y6T8 [Direct mapping]
Ras-related protein Rab-18
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 291 aa
32.9 kDa 		No 1
RAB18-201
ENSP00000439321
ENST00000535776
Q9NP72 [Direct mapping]
Ras-related protein Rab-18
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001654 [eye development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0032482 [Rab protein signal transduction]
GO:0034389 [lipid particle organization]
GO:0070062 [extracellular exosome]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0071786 [endoplasmic reticulum tubular network organization]
Show all
 142 aa
15.5 kDa 		No 0
RAB18-202
ENSP00000483927
ENST00000611151
A0A087X163 [Direct mapping]
Ras-related protein Rab-18
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 182 aa
20.4 kDa 		No 0
RAB18-203
ENSP00000478479
ENST00000621805
Q9NP72 [Direct mapping]
Ras-related protein Rab-18
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001654 [eye development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0032482 [Rab protein signal transduction]
GO:0034389 [lipid particle organization]
GO:0070062 [extracellular exosome]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0071786 [endoplasmic reticulum tubular network organization]
Show all
 235 aa
26.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.