Cell atlas - MZF1 - The Human Protein Atlas

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MZF1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MZF1
Gene description	Myeloid zinc finger 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA001757
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001757	A-431	Nucleus
	HPA001757	HEK 293	No staining
	HPA001757	U-2 OS	No staining

GENE INFORMATION
Gene name	MZF1 (HGNC Symbol)
Synonyms	MZF-1, MZF1B, Zfp98, ZNF42, ZSCAN6
Description	Myeloid zinc finger 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	58561931 - 58573575
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099326 (version 83.38)
Entrez gene	7593
UniProt	P28698 (UniProt - Evidence at protein level)
neXtProt	NX_P28698
Antibodypedia	MZF1 antibodies

PROTEIN BROWSER

MZF1-001	MZF1-002	MZF1-003	MZF1-004	MZF1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MZF1-001 ENSP00000215057 ENST00000215057	P28698 [Direct mapping] Myeloid zinc finger 1 A0A024R4T5 [Target identity:100%; Query identity:100%] Zinc finger protein 42 (Myeloid-specific retinoic acid-responsive), isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0042803 [protein homodimerization activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	734 aa 82.1 kDa	No	0
MZF1-002 ENSP00000469493 ENST00000599369	P28698 [Direct mapping] Myeloid zinc finger 1 A0A024R4T5 [Target identity:100%; Query identity:100%] Zinc finger protein 42 (Myeloid-specific retinoic acid-responsive), isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0042803 [protein homodimerization activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	734 aa 82.1 kDa	No	0
MZF1-003 ENSP00000469378 ENST00000594234	P28698 [Direct mapping] Myeloid zinc finger 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0042803 [protein homodimerization activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	290 aa 31.5 kDa	No	0
MZF1-004 ENSP00000472123 ENST00000594108	M0R1U5 [Direct mapping] Myeloid zinc finger 1 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	259 aa 28.7 kDa	No	0
MZF1-008 ENSP00000472454 ENST00000596039	M0R2C0 [Direct mapping] Myeloid zinc finger 1 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	63 aa 6.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.