Cell atlas - FBXL19 - The Human Protein Atlas

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FBXL19

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	FBXL19
Gene description	F-box and leucine-rich repeat protein 19
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035317
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the intermediate filaments.

Main location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035317	A-431	Intermediate filaments	Intensity
	HPA035317	U-2 OS	Intermediate filaments	Intensity

GENE INFORMATION
Gene name	FBXL19 (HGNC Symbol)
Synonyms	CXXC11, DKFZp434K0410, Fbl19, JHDM1C
Description	F-box and leucine-rich repeat protein 19 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30923055 - 30948783
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099364 (version 83.38)
Entrez gene	54620
UniProt	Q6PCT2 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PCT2
Antibodypedia	FBXL19 antibodies

PROTEIN BROWSER

FBXL19-001	FBXL19-002	FBXL19-003	FBXL19-004	FBXL19-005	FBXL19-007	FBXL19-008	FBXL19-009	FBXL19-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL19-001 ENSP00000455529 ENST00000562319	H3BPZ0 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	674 aa 73.8 kDa	No	0
FBXL19-002 ENSP00000339712 ENST00000338343	H3BPZ0 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	674 aa 73.8 kDa	No	0
FBXL19-003 ENSP00000397913 ENST00000427128	H7C112 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	586 aa 64.3 kDa	No	0
FBXL19-004 ENSP00000458033 ENST00000471231	H3BVB1 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	382 aa 42.3 kDa	No	0
FBXL19-005 ENSP00000454344 ENST00000565690	H3BME1 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	558 aa 61.7 kDa	No	0
FBXL19-007 ENSP00000455871 ENST00000562798	H3BQP6 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0008270 [zinc ion binding] Show all	59 aa 6.6 kDa	No	0
FBXL19-008 ENSP00000455337 ENST00000566320	H3BPI8 [Direct mapping] F-box/LRR-repeat protein 19 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 14.8 kDa	No	0
FBXL19-009 ENSP00000457199 ENST00000565939	H3BTJ3 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13 kDa	No	0
FBXL19-201 ENSP00000369666 ENST00000380310	Q6PCT2 [Direct mapping] F-box/LRR-repeat protein 19 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	694 aa 75.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.