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Membranous staining of various intensities was observed in carcinoid. Neuropil in gliomas showed strong cytoplasmic staining. All other cancers were negative.
GENE INFORMATION
Gene name
STX1B (HGNC Symbol)
Synonyms
STX1B1, STX1B2
Description
Syntaxin 1B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]