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SETD1A

CANCER ATLAS

Gene description

 SET domain containing 1A

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020646
HPA058376

GENE INFORMATION

Gene name

 SETD1A (HGNC Symbol)

Synonyms

 KIAA0339, KMT2F, Set1

Description

 SET domain containing 1A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Jan 2015]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 30957294 - 30985116

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099381 (version 83.38)

Entrez gene

 9739

UniProt

 O15047 (UniProt - Evidence at protein level)

neXtProt

 NX_O15047

Antibodypedia

 SETD1A antibodies

PROTEIN BROWSER
SETD1A-001
SETD1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SETD1A-001
ENSP00000262519
ENST00000262519
O15047 [Direct mapping]
Histone-lysine N-methyltransferase SETD1A
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0016607 [nuclear speck]
GO:0035097 [histone methyltransferase complex]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0048188 [Set1C/COMPASS complex]
GO:0051568 [histone H3-K4 methylation]
Show all
 1707 aa
186 kDa 		No 0
SETD1A-002
ENSP00000391408
ENST00000452917
C9J2Z9 [Direct mapping]
Histone-lysine N-methyltransferase SETD1A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 247 aa
27.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.