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ATP5D

CANCER ATLAS

Gene description

 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002865

GENE INFORMATION

Gene name

 ATP5D

Synonyms

Description

 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1241746 - 1244826

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099624 (version 83.38)

Entrez gene

 513

UniProt

 P30049 (UniProt - Evidence at protein level)

neXtProt

 NX_P30049

Antibodypedia

 ATP5D antibodies

PROTEIN BROWSER
ATP5D-001
ATP5D-006
ATP5D-008
ATP5D-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5D-001
ENSP00000215375
ENST00000215375
P30049 [Direct mapping]
ATP synthase subunit delta, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0006119 [oxidative phosphorylation]
GO:0006754 [ATP biosynthetic process]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0043531 [ADP binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046688 [response to copper ion]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 168 aa
17.5 kDa 		No 0
ATP5D-006
ENSP00000464863
ENST00000591660
P30049 [Direct mapping]
ATP synthase subunit delta, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0006119 [oxidative phosphorylation]
GO:0006754 [ATP biosynthetic process]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0043531 [ADP binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046688 [response to copper ion]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 168 aa
17.5 kDa 		No 0
ATP5D-008
ENSP00000378995
ENST00000395633
P30049 [Direct mapping]
ATP synthase subunit delta, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0006119 [oxidative phosphorylation]
GO:0006754 [ATP biosynthetic process]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0043531 [ADP binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046688 [response to copper ion]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 168 aa
17.5 kDa 		No 0
ATP5D-009
ENSP00000477964
ENST00000591249
A0A087WTL3 [Direct mapping]
ATP synthase subunit delta, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 99 aa
10.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.