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Colorectal, prostate, endometrial, gastric, pancreatic and cholangicellular cancers showed moderate to strong cytoplasmic positivity. Remaining tumor cells were generally negative.
GENE INFORMATION
Gene name
PCDH11Y (HGNC Symbol)
Synonyms
PCDH22, PCDHY
Description
Protocadherin 11 Y-linked (HGNC Symbol)
Entrez gene summary
This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
