Cell atlas - MARCH2 - The Human Protein Atlas

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MARCH2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MARCH2
Gene description	Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA014063
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014063	U-2 OS	Cytosol
	HPA014063	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MARCH2 (HGNC Symbol)
Synonyms	HSPC240, MARCH-II, RNF172
Description	Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8413270 - 8439017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099785 (version 83.38)
Entrez gene	51257
UniProt	Q9P0N8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0N8
Antibodypedia	MARCH2 antibodies

PROTEIN BROWSER

MARCH2-001	MARCH2-002	MARCH2-003	MARCH2-004	MARCH2-005	MARCH2-006	MARCH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH2-001 ENSP00000471536 ENST00000602117	Q9P0N8 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006897 [endocytosis] GO:0008270 [zinc ion binding] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031410 [cytoplasmic vesicle] Show all	246 aa 27 kDa	No	2
MARCH2-002 ENSP00000370423 ENST00000381035	Q9P0N8 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006897 [endocytosis] GO:0008270 [zinc ion binding] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031410 [cytoplasmic vesicle] Show all	176 aa 19.1 kDa	No	0
MARCH2-003 ENSP00000472027 ENST00000595142	M0R1P2 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted intracellular proteins Show all		79 aa 8.2 kDa	No	0
MARCH2-004 ENSP00000471411 ENST00000595213	M0R0S4 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted intracellular proteins Show all		56 aa 5.8 kDa	No	0
MARCH2-005 ENSP00000469386 ENST00000601283	M0QXU4 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted intracellular proteins Show all		40 aa 4 kDa	No	0
MARCH2-006 ENSP00000471619 ENST00000601724	M0R138 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted intracellular proteins Show all		80 aa 8.3 kDa	No	0
MARCH2-201 ENSP00000215555 ENST00000215555	Q9P0N8 [Direct mapping] E3 ubiquitin-protein ligase MARCH2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006897 [endocytosis] GO:0008270 [zinc ion binding] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031410 [cytoplasmic vesicle] Show all	246 aa 27 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.