Cell atlas - TECR - The Human Protein Atlas

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TECR

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	TECR
Gene description	Trans-2,3-enoyl-CoA reductase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA056488
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056488	MCF7	Endoplasmic reticulum
	HPA056488	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	TECR (HGNC Symbol)
Synonyms	GPSN2, MRT14, SC2, TER
Description	Trans-2,3-enoyl-CoA reductase (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14517085 - 14565980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099797 (version 83.38)
Entrez gene	9524
UniProt	Q9NZ01 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZ01
Antibodypedia	TECR antibodies

PROTEIN BROWSER

TECR-001	TECR-002	TECR-003	TECR-007	TECR-009	TECR-011	TECR-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TECR-001 ENSP00000215567 ENST00000215567	Q9NZ01 [Direct mapping] Very-long-chain enoyl-CoA reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0019432 [triglyceride biosynthetic process] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030497 [fatty acid elongation] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042761 [very long-chain fatty acid biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	308 aa 36 kDa	No	5
TECR-002 ENSP00000472697 ENST00000596073	B4DR74 [Direct mapping] Very-long-chain enoyl-CoA reductase; cDNA FLJ58248, highly similar to Synaptic glycoprotein SC2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process] Show all	153 aa 17.8 kDa	No	4
TECR-003 ENSP00000472114 ENST00000600083	B4DR74 [Direct mapping] Very-long-chain enoyl-CoA reductase; cDNA FLJ58248, highly similar to Synaptic glycoprotein SC2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process] Show all	153 aa 17.8 kDa	No	4
TECR-007 ENSP00000471341 ENST00000598298	M0R0N5 [Direct mapping] Very-long-chain enoyl-CoA reductase Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.5 kDa	No	0
TECR-009 ENSP00000469263 ENST00000598715	M0QXM3 [Direct mapping] Very-long-chain enoyl-CoA reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	132 aa 15 kDa	No	1
TECR-011 ENSP00000469343 ENST00000594545	M0QXS1 [Direct mapping] Very-long-chain enoyl-CoA reductase Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 5.1 kDa	No	0
TECR-021 ENSP00000472957 ENST00000601187	M0R329 [Direct mapping] Very-long-chain enoyl-CoA reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process] Show all	150 aa 16.8 kDa	Yes	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.