Cell atlas - TIMM13 - The Human Protein Atlas

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TIMM13

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoli fibrillar center

Human cell
	Mitochondria
	Nucleoli

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GENERAL INFORMATION
Gene name	TIMM13
Gene description	Translocase of inner mitochondrial membrane 13 homolog (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoli (fibrillar center).
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA048985
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoli (fibrillar center).

Main location

Mitochondria (supported)

Additional location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048985	HEK 293	Nucleoli fibrillar center
	HPA048985	HEK 293	Mitochondria
	HPA048985	HeLa	Mitochondria
	HPA048985	U-2 OS	Nucleoli fibrillar center
	HPA048985	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	TIMM13 (HGNC Symbol)
Synonyms	Tim13, TIMM13B
Description	Translocase of inner mitochondrial membrane 13 homolog (yeast) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2425624 - 2427894
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099800 (version 83.38)
Entrez gene	26517
UniProt	Q9Y5L4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5L4
Antibodypedia	TIMM13 antibodies

PROTEIN BROWSER

TIMM13-001	TIMM13-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIMM13-001 ENSP00000215570 ENST00000215570	Q9Y5L4 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim13 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006626 [protein targeting to mitochondrion] GO:0007605 [sensory perception of sound] GO:0008270 [zinc ion binding] GO:0042719 [mitochondrial intermembrane space protein transporter complex] GO:0044267 [cellular protein metabolic process] GO:0072321 [chaperone-mediated protein transport] Show all	95 aa 10.5 kDa	No	0
TIMM13-002 ENSP00000464881 ENST00000591871	K7EIT2 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim13; Translocase of inner mitochondrial membrane 13 homolog (Yeast), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0015031 [protein transport] GO:0046872 [metal ion binding] Show all	80 aa 8.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.