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Cancer tissues displayed moderate cytoplasmic and membranous immunoreactivity. Additional nuclear staining was observed in few cases. Few breast, cervical, ovarian and endometrial carcinomas and gliomas showed strong staining. Lymphomas, melanomas and skin cancers were either weakly stained or negative.
A majority of cancer cells showed weak to moderate cytoplasmic positivity. Testicular cancers along with several cases of renal, colorectal, urothelial and cancers of female genital tract were negative.
GENE INFORMATION
Gene name
CDC34 (HGNC Symbol)
Synonyms
E2-CDC34, UBC3, UBE2R1
Description
Cell division cycle 34 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006270 [DNA replication initiation] GO:0006464 [cellular protein modification process] GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0035458 [cellular response to interferon-beta] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043951 [negative regulation of cAMP-mediated signaling] GO:0061630 [ubiquitin protein ligase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070848 [response to growth factor] GO:0070936 [protein K48-linked ubiquitination] GO:0090261 [positive regulation of inclusion body assembly]
