Cell atlas - POLRMT - The Human Protein Atlas

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POLRMT

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	POLRMT
Gene description	Polymerase (RNA) mitochondrial (DNA directed)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006366
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006366	HEK 293	Mitochondria
	HPA006366	U-2 OS	Mitochondria
	HPA006366	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	POLRMT (HGNC Symbol)
Synonyms	APOLMT, h-mtRPOL, MTRNAP, MTRPOL
Description	Polymerase (RNA) mitochondrial (DNA directed) (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	617224 - 633604
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099821 (version 83.38)
Entrez gene	5442
UniProt	O00411 (UniProt - Evidence at protein level)
neXtProt	NX_O00411
Antibodypedia	POLRMT antibodies

PROTEIN BROWSER

POLRMT-001	POLRMT-002	POLRMT-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLRMT-001 ENSP00000465759 ENST00000588649	O00411 [Direct mapping] DNA-directed RNA polymerase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006390 [transcription from mitochondrial promoter] GO:0006391 [transcription initiation from mitochondrial promoter] GO:0006996 [organelle organization] GO:0007005 [mitochondrion organization] GO:0010467 [gene expression] GO:0042645 [mitochondrial nucleoid] GO:0044822 [poly(A) RNA binding] Show all	1230 aa 138.6 kDa	No	0
POLRMT-002 ENSP00000466504 ENST00000590573	K7EMH3 [Direct mapping] DNA-directed RNA polymerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated] Show all	347 aa 38.9 kDa	No	0
POLRMT-004 ENSP00000468658 ENST00000590336	K7ESD1 [Direct mapping] DNA-directed RNA polymerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated] Show all	127 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.