We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Few cases of ovarian cancers showed moderate membranous staining. Papillary adenocarcinoma of thyroid along with few endometrial, prostate and testicular cancers exhibited weak membranous and/or cytoplasmic staining. Remaining cancer tissues were negative.
Distinct cytoplasmic staining was observed in most malignant lymphomas. Moderate cytoplasmic and/or membranous positivity was observed in cases of malignant carcinoids, prostate, thyroid and testicular cancers. Remaining cancers were in general negative.
GENE INFORMATION
Gene name
ARVCF
Synonyms
Description
Armadillo repeat gene deleted in velocardiofacial syndrome (HGNC Symbol)
Entrez gene summary
Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010]
