Expression of TRMT2A in cancer - Summary

CANCER ATLAS

Gene description

TRNA methyltransferase 2 homolog A

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001077

GENE INFORMATION
Gene name	TRMT2A (HGNC Symbol)
Synonyms	HTF9C
Description	TRNA methyltransferase 2 homolog A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	20111866 - 20117392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099899 (version 83.38)
Entrez gene	27037
UniProt	Q8IZ69 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZ69
Antibodypedia	TRMT2A antibodies

PROTEIN BROWSER

TRMT2A-001	TRMT2A-002	TRMT2A-003	TRMT2A-005	TRMT2A-006	TRMT2A-016	TRMT2A-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRMT2A-001 ENSP00000252136 ENST00000252136	Q8IZ69 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001510 [RNA methylation] GO:0003676 [nucleic acid binding] GO:0006396 [RNA processing] GO:0008173 [RNA methyltransferase activity] GO:0044822 [poly(A) RNA binding] Show all	625 aa 68.7 kDa	No	0
TRMT2A-002 ENSP00000384968 ENST00000404751	Q8IZ69 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001510 [RNA methylation] GO:0003676 [nucleic acid binding] GO:0006396 [RNA processing] GO:0008173 [RNA methyltransferase activity] GO:0044822 [poly(A) RNA binding] Show all	562 aa 62 kDa	No	0
TRMT2A-003 ENSP00000395738 ENST00000439169	F2Z2W7 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001510 [RNA methylation] GO:0003676 [nucleic acid binding] GO:0006396 [RNA processing] GO:0008173 [RNA methyltransferase activity] Show all	643 aa 70.8 kDa	No	0
TRMT2A-005 ENSP00000385807 ENST00000403707	Q8IZ69 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001510 [RNA methylation] GO:0003676 [nucleic acid binding] GO:0006396 [RNA processing] GO:0008173 [RNA methyltransferase activity] GO:0044822 [poly(A) RNA binding] Show all	625 aa 68.7 kDa	No	0
TRMT2A-006 ENSP00000393911 ENST00000445045	C9K041 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	120 aa 12.9 kDa	No	0
TRMT2A-016 ENSP00000397744 ENST00000444845	H7C100 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001510 [RNA methylation] GO:0006396 [RNA processing] GO:0008173 [RNA methyltransferase activity] Show all	158 aa 17.2 kDa	No	0
TRMT2A-019 ENSP00000392261 ENST00000444256	H7BZZ4 [Direct mapping] tRNA (uracil-5-)-methyltransferase homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 15.1 kDa	No	0