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MED15

GENERAL INFORMATION

Gene name

 MED15

Gene description

 Mediator complex subunit 15

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003179
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MED15 (HGNC Symbol)

Synonyms

 Arc105, CAG7A, PCQAP, TIG-1, TNRC7

Description

 Mediator complex subunit 15 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 20495913 - 20587632

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099917 (version 83.38)

Entrez gene

 51586

UniProt

 Q96RN5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RN5

Antibodypedia

 MED15 antibodies

PROTEIN BROWSER
«
MED15-001
MED15-004
MED15-005
MED15-006
MED15-010
MED15-011
MED15-014
MED15-015
MED15-016
MED15-017
MED15-020
MED15-021
MED15-022
MED15-023
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED15-001
ENSP00000292733
ENST00000292733
Q96RN5 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
Show all
 748 aa
82.6 kDa 		No 0
MED15-004
ENSP00000263205
ENST00000263205
Q96RN5 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0019827 [stem cell population maintenance]
Show all
 788 aa
86.8 kDa 		No 0
MED15-005
ENSP00000384344
ENST00000406969
G3V1P5 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15; PC2 (Positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, isoform CRA_f
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 722 aa
79.6 kDa 		No 0
MED15-006
ENSP00000372434
ENST00000382974
Q96RN5 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
Show all
 677 aa
75.9 kDa 		No 0
MED15-010
ENSP00000392738
ENST00000414658
C9J1I1 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 141 aa
14.7 kDa 		No 0
MED15-011
ENSP00000408794
ENST00000432052
C9JLN7 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 106 aa
12.3 kDa 		No 0
MED15-014
ENSP00000410173
ENST00000438962
C9JEM1 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 119 aa
13 kDa 		No 0
MED15-015
ENSP00000407742
ENST00000445987
C9JZV5 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 120 aa
12.3 kDa 		No 0
MED15-016
ENSP00000390498
ENST00000445189
C9JGN2 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 124 aa
12.7 kDa 		No 0
MED15-017
ENSP00000408742
ENST00000451058
C9JM58 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 105 aa
10.9 kDa 		No 0
MED15-020
ENSP00000415778
ENST00000457322
C9JJ12 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 160 aa
17.2 kDa 		No 0
MED15-021
ENSP00000413603
ENST00000428629
C9JWK5 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 82 aa
9.6 kDa 		No 0
MED15-022
ENSP00000396461
ENST00000424287
C9JCQ3 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 165 aa
17.7 kDa 		No 0
MED15-023
ENSP00000408875
ENST00000423862
H7C308 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 194 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.