Cell atlas - DERL3 - The Human Protein Atlas

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DERL3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	DERL3
Gene description	Derlin 3
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Group enriched (U-266/70, Karpas-707, RPMI-8226, U-698)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA049306
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/70, Karpas-707, RPMI-8226, U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049306	HEK 293	Vesicles
	HPA049306	HeLa	No staining
	HPA049306	U-2 OS	Vesicles

GENE INFORMATION
Gene name	DERL3 (HGNC Symbol)
Synonyms	C22orf14, derlin-3, FLJ43842, IZP6, MGC71803
Description	Derlin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	23834503 - 23839128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099958 (version 83.38)
Entrez gene	91319
UniProt	Q96Q80 (UniProt - Evidence at protein level)
neXtProt	NX_Q96Q80
Antibodypedia	DERL3 antibodies

PROTEIN BROWSER

DERL3-001	DERL3-002	DERL3-003	DERL3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DERL3-001 ENSP00000384744 ENST00000406855	Q96Q80 [Direct mapping] Derlin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	239 aa 26.6 kDa	No	4
DERL3-002 ENSP00000315303 ENST00000318109	Q96Q80 [Direct mapping] Derlin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	235 aa 26.7 kDa	No	5
DERL3-003 ENSP00000419399 ENST00000476077	Q96Q80 [Direct mapping] Derlin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	205 aa 23.4 kDa	No	5
DERL3-005 ENSP00000384473 ENST00000404056	E7EVA4 [Direct mapping] Derlin-3 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		178 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.