Cell atlas - BCL2L13 - The Human Protein Atlas

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BCL2L13

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	BCL2L13
Gene description	BCL2-like 13 (apoptosis facilitator)
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA030994 , HPA050377
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030994	A-431	Mitochondria
	HPA030994	HaCaT	Mitochondria
	HPA050377	A-431	Mitochondria
	HPA050377	MCF7	Mitochondria
	HPA050377	U-2 OS	Cytosol

GENE INFORMATION
Gene name	BCL2L13 (HGNC Symbol)
Synonyms	BCL-RAMBO, MIL1
Description	BCL2-like 13 (apoptosis facilitator) (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	17628855 - 17730855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099968 (version 83.38)
Entrez gene	23786
UniProt	Q9BXK5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXK5
Antibodypedia	BCL2L13 antibodies

PROTEIN BROWSER

BCL2L13-001	BCL2L13-002	BCL2L13-004	BCL2L13-005	BCL2L13-201	BCL2L13-202	BCL2L13-203	BCL2L13-204	BCL2L13-205	BCL2L13-206	BCL2L13-207

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL2L13-001 ENSP00000318883 ENST00000317582	Q9BXK5 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0042981 [regulation of apoptotic process] Show all	485 aa 52.7 kDa	No	1
BCL2L13-002 ENSP00000382682 ENST00000399782	Q9BXK5 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0042981 [regulation of apoptotic process] Show all	201 aa 22.6 kDa	No	0
BCL2L13-004 ENSP00000434764 ENST00000493680	Q9BXK5 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0042981 [regulation of apoptotic process] Show all	201 aa 22.6 kDa	No	0
BCL2L13-005 ENSP00000347133 ENST00000355028	E9PDD6 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 19 kDa	No	0
BCL2L13-201 ENSP00000338932 ENST00000337612	A0A0A0MR90 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 14.3 kDa	No	0
BCL2L13-202 ENSP00000410019 ENST00000418951	Q9BXK5 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] Show all	323 aa 34.6 kDa	No	1
BCL2L13-203 ENSP00000441344 ENST00000538149	F6VJB4 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.2 kDa	No	0
BCL2L13-204 ENSP00000437667 ENST00000543133	Q9BXK5 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] Show all	323 aa 34.6 kDa	No	1
BCL2L13-205 ENSP00000477967 ENST00000611738	A0A087WTL4 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	461 aa 48.9 kDa	No	1
BCL2L13-206 ENSP00000480014 ENST00000616863	A0A087WW80 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 8.9 kDa	No	0
BCL2L13-207 ENSP00000480836 ENST00000618481	A0A087WX97 [Direct mapping] Bcl-2-like protein 13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0042981 [regulation of apoptotic process] Show all	509 aa 54.4 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.