Tissue expression of SPECC1L - Summary - The Human Protein Atlas

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SPECC1L

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SPECC1L
Gene description	Sperm antigen with calponin homology and coiled-coil domains 1-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Not detected
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA070614
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SPECC1L (HGNC Symbol)
Synonyms	CYTSA, KIAA0376
Description	Sperm antigen with calponin homology and coiled-coil domains 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24270817 - 24417740
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100014 (version 83.38)
Entrez gene	23384
UniProt	Q69YQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q69YQ0
Antibodypedia	SPECC1L antibodies

PROTEIN BROWSER

SPECC1L-001	SPECC1L-002	SPECC1L-003	SPECC1L-006	SPECC1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPECC1L-001 ENSP00000325785 ENST00000314328	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1117 aa 124.5 kDa	No	0
SPECC1L-002 ENSP00000405671 ENST00000421374	C9J8U1 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		789 aa 88.3 kDa	No	0
SPECC1L-003 ENSP00000414354 ENST00000440893	C9JLY8 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 18.9 kDa	No	0
SPECC1L-006 ENSP00000439633 ENST00000541492	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1078 aa 120.1 kDa	No	0
SPECC1L-201 ENSP00000393363 ENST00000437398	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1117 aa 124.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.