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PPIL2

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GENERAL INFORMATION

Gene name

 PPIL2

Gene description

 Peptidylprolyl isomerase (cyclophilin)-like 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA035344 , HPA055637
SHOW MORE

ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035344 A-431 Nucleoplasm
HPA035344 U-2 OS Nucleoplasm
HPA035344 U-251 MG Nucleoplasm
HPA055637 A-431 Nucleoplasm
HPA055637 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000022771 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA055637 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 PPIL2 (HGNC Symbol)

Synonyms

 CYC4, Cyp-60, UBOX7

Description

 Peptidylprolyl isomerase (cyclophilin)-like 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

Chromosome location (bp)

 21652270 - 21700015

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100023 (version 83.38)

Entrez gene

 23759

UniProt

 Q13356 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13356

Antibodypedia

 PPIL2 antibodies

PROTEIN BROWSER
PPIL2-001
PPIL2-005
PPIL2-006
PPIL2-009
PPIL2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPIL2-001
ENSP00000334553
ENST00000335025
Q13356 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase-like 2
A0A024R1C1 [Target identity:100%; Query identity:100%]
Peptidylprolyl isomerase (Cyclophilin)-like 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0050900 [leukocyte migration]
GO:0061630 [ubiquitin protein ligase activity]
GO:0072659 [protein localization to plasma membrane]
Show all
 520 aa
58.8 kDa 		No 0
PPIL2-005
ENSP00000384299
ENST00000406385
Q13356 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase-like 2
A0A024R1C1 [Target identity:100%; Query identity:100%]
Peptidylprolyl isomerase (Cyclophilin)-like 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0050900 [leukocyte migration]
GO:0061630 [ubiquitin protein ligase activity]
GO:0072659 [protein localization to plasma membrane]
Show all
 520 aa
58.8 kDa 		No 0
PPIL2-006
ENSP00000381812
ENST00000398831
Q13356 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase-like 2
A0A024R1C1 [Target identity:100%; Query identity:100%]
Peptidylprolyl isomerase (Cyclophilin)-like 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0050900 [leukocyte migration]
GO:0061630 [ubiquitin protein ligase activity]
GO:0072659 [protein localization to plasma membrane]
Show all
 520 aa
58.8 kDa 		No 0
PPIL2-009
ENSP00000395181
ENST00000458567
C9JDF0 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase-like 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
Show all
 160 aa
18.2 kDa 		No 0
PPIL2-013
ENSP00000486725
ENST00000626352
Q13356 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase-like 2
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0050900 [leukocyte migration]
GO:0061630 [ubiquitin protein ligase activity]
GO:0072659 [protein localization to plasma membrane]
Show all
 527 aa
59.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.