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MAPK1

CANCER ATLAS

Gene description

 Mitogen-activated protein kinase 1

Protein class

 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003995
HPA005700
HPA030069
CAB004229

GENE INFORMATION

Gene name

 MAPK1 (HGNC Symbol)

Synonyms

 ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2

Description

 Mitogen-activated protein kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Chromosome

 22

Cytoband

 q11.22

Chromosome location (bp)

 21754500 - 21867680

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100030 (version 83.38)

Entrez gene

 5594

UniProt

 P28482 (UniProt - Evidence at protein level)

neXtProt

 NX_P28482

Antibodypedia

 MAPK1 antibodies

PROTEIN BROWSER
MAPK1-001
MAPK1-002
MAPK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK1-001
ENSP00000215832
ENST00000215832
P28482 [Direct mapping]
Mitogen-activated protein kinase 1
Q1HBJ4 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000189 [MAPK import into nucleus]
GO:0001784 [phosphotyrosine binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0009887 [organ morphogenesis]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0014032 [neural crest cell development]
GO:0015630 [microtubule cytoskeleton]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019233 [sensory perception of pain]
GO:0019858 [cytosine metabolic process]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030878 [thyroid gland development]
GO:0031143 [pseudopodium]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0031647 [regulation of protein stability]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032839 [dendrite cytoplasm]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042473 [outer ear morphogenesis]
GO:0043204 [perikaryon]
GO:0043234 [protein complex]
GO:0043330 [response to exogenous dsRNA]
GO:0043627 [response to estrogen]
GO:0045087 [innate immune response]
GO:0045596 [negative regulation of cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048538 [thymus development]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060291 [long-term synaptic potentiation]
GO:0060324 [face development]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0060425 [lung morphogenesis]
GO:0060440 [trachea formation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061308 [cardiac neural crest cell development involved in heart development]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070849 [response to epidermal growth factor]
GO:0071310 [cellular response to organic substance]
GO:0072584 [caveolin-mediated endocytosis]
GO:0072686 [mitotic spindle]
GO:0090170 [regulation of Golgi inheritance]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
GO:1900034 [regulation of cellular response to heat]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 360 aa
41.4 kDa 		No 0
MAPK1-002
ENSP00000381803
ENST00000398822
P28482 [Direct mapping]
Mitogen-activated protein kinase 1
Q1HBJ4 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006950 [response to stress]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0015630 [microtubule cytoskeleton]
GO:0016032 [viral process]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019902 [phosphatase binding]
GO:0030168 [platelet activation]
GO:0031647 [regulation of protein stability]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070849 [response to epidermal growth factor]
GO:0072584 [caveolin-mediated endocytosis]
GO:0072686 [mitotic spindle]
GO:0090170 [regulation of Golgi inheritance]
GO:1900034 [regulation of cellular response to heat]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 360 aa
41.4 kDa 		No 0
MAPK1-201
ENSP00000440842
ENST00000544786
P28482 [Direct mapping]
Mitogen-activated protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006950 [response to stress]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0015630 [microtubule cytoskeleton]
GO:0016032 [viral process]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019902 [phosphatase binding]
GO:0030168 [platelet activation]
GO:0031647 [regulation of protein stability]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070849 [response to epidermal growth factor]
GO:0072584 [caveolin-mediated endocytosis]
GO:0072686 [mitotic spindle]
GO:0090170 [regulation of Golgi inheritance]
GO:1900034 [regulation of cellular response to heat]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 316 aa
36.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.