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PPM1F

GENERAL INFORMATION

Gene name

 PPM1F

Gene description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1F

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA030989 , HPA030990
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPM1F (HGNC Symbol)

Synonyms

 CAMKP, CaMKPase, FEM-2, KIAA0015, POPX2

Description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1F (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q11.22

Chromosome location (bp)

 21919420 - 21952837

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100034 (version 83.38)

Entrez gene

 9647

UniProt

 P49593 (UniProt - Evidence at protein level)

neXtProt

 NX_P49593

Antibodypedia

 PPM1F antibodies

PROTEIN BROWSER
PPM1F-001
PPM1F-002
PPM1F-003
PPM1F-004
PPM1F-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPM1F-001
ENSP00000263212
ENST00000263212
P49593 [Direct mapping]
Protein phosphatase 1F
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0010628 [positive regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016576 [histone dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033192 [calmodulin-dependent protein phosphatase activity]
GO:0035690 [cellular response to drug]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0043169 [cation binding]
GO:0043234 [protein complex]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045927 [positive regulation of growth]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050921 [positive regulation of chemotaxis]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 454 aa
49.8 kDa 		No 0
PPM1F-002
ENSP00000384930
ENST00000407142
B5MCT7 [Direct mapping]
Protein phosphatase 1F; Protein phosphatase 1F (PP2C domain containing), isoform CRA_a
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
GO:0046872 [metal ion binding]
Show all
 286 aa
31.3 kDa 		No 0
PPM1F-003
ENSP00000380632
ENST00000397495
A8MX49 [Direct mapping]
Protein phosphatase 1F; Protein phosphatase 1F (PP2C domain containing), isoform CRA_b
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
GO:0046872 [metal ion binding]
Show all
 361 aa
40.1 kDa 		No 0
PPM1F-004
ENSP00000392372
ENST00000445205
C9J2F3 [Direct mapping]
Protein phosphatase 1F
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
Show all
 90 aa
10.1 kDa 		No 0
PPM1F-007
ENSP00000388350
ENST00000424647
C9JL74 [Direct mapping]
Protein phosphatase 1F
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
Show all
 82 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.