Cell atlas - TOP3B - The Human Protein Atlas

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TOP3B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	TOP3B
Gene description	Topoisomerase (DNA) III beta
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA069678
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA069678	HaCaT	Vesicles
	HPA069678	U-2 OS	Vesicles

GENE INFORMATION
Gene name	TOP3B
Synonyms
Description	Topoisomerase (DNA) III beta (HGNC Symbol)
Entrez gene summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Chromosome	22
Cytoband	q11.22
Chromosome location (bp)	21957025 - 21982816
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100038 (version 83.38)
Entrez gene	8940
UniProt	O95985 (UniProt - Evidence at protein level)
neXtProt	NX_O95985
Antibodypedia	TOP3B antibodies

PROTEIN BROWSER

TOP3B-001	TOP3B-003	TOP3B-006	TOP3B-007	TOP3B-008	TOP3B-009	TOP3B-010	TOP3B-011	TOP3B-012	TOP3B-013	TOP3B-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOP3B-001 ENSP00000349705 ENST00000357179	O95985 [Direct mapping] DNA topoisomerase 3-beta-1 A0A024R1C2 [Target identity:100%; Query identity:100%] DNA topoisomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003916 [DNA topoisomerase activity] GO:0003917 [DNA topoisomerase type I activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006265 [DNA topological change] GO:0044822 [poly(A) RNA binding] Show all	862 aa 96.7 kDa	No	0
TOP3B-003 ENSP00000381773 ENST00000398793	O95985 [Direct mapping] DNA topoisomerase 3-beta-1 A0A024R1C2 [Target identity:100%; Query identity:100%] DNA topoisomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000793 [condensed chromosome] GO:0003677 [DNA binding] GO:0003916 [DNA topoisomerase activity] GO:0003917 [DNA topoisomerase type I activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006265 [DNA topological change] GO:0007059 [chromosome segregation] GO:0044822 [poly(A) RNA binding] Show all	862 aa 96.7 kDa	No	0
TOP3B-006 ENSP00000408282 ENST00000457270	H0Y6W0 [Direct mapping] DNA topoisomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003916 [DNA topoisomerase activity] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	525 aa 59.3 kDa	No	0
TOP3B-007 ENSP00000414538 ENST00000430142	C9JKE2 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	121 aa 13.4 kDa	No	0
TOP3B-008 ENSP00000390824 ENST00000434517	C9JF56 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.3 kDa	No	0
TOP3B-009 ENSP00000391857 ENST00000456075	C9J9X4 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	61 aa 6.4 kDa	No	0
TOP3B-010 ENSP00000387554 ENST00000437103	C9JTQ7 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	42 aa 4.4 kDa	No	0
TOP3B-011 ENSP00000404600 ENST00000449704	C9JEQ1 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	60 aa 6.3 kDa	No	0
TOP3B-012 ENSP00000390977 ENST00000424393	C9JEI7 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003916 [DNA topoisomerase activity] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	246 aa 27.4 kDa	No	0
TOP3B-013 ENSP00000402622 ENST00000437929	C9JT00 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	122 aa 13.5 kDa	No	0
TOP3B-014 ENSP00000390209 ENST00000442653	C9JHR0 [Direct mapping] DNA topoisomerase 3-beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003917 [DNA topoisomerase type I activity] GO:0006265 [DNA topological change] Show all	47 aa 4.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.