Expression of MFNG in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA048936

GENE INFORMATION
Gene name	MFNG
Synonyms
Description	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (HGNC Symbol)
Entrez gene summary	This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37469063 - 37486401
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100060 (version 83.38)
Entrez gene	4242
UniProt	O00587 (UniProt - Evidence at protein level)
neXtProt	NX_O00587
Antibodypedia	MFNG antibodies

PROTEIN BROWSER

MFNG-001	MFNG-004	MFNG-005	MFNG-007	MFNG-010	MFNG-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFNG-001 ENSP00000349490 ENST00000356998	O00587 [Direct mapping] Beta-1,3-N-acetylglucosaminyltransferase manic fringe Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0002315 [marginal zone B cell differentiation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007389 [pattern specification process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030173 [integral component of Golgi membrane] GO:0032092 [positive regulation of protein binding] GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity] GO:0045747 [positive regulation of Notch signaling pathway] GO:0046872 [metal ion binding] Show all	321 aa 36.2 kDa	Yes	0
MFNG-004 ENSP00000389274 ENST00000442496	A9UJQ0 [Direct mapping] Beta-1,3-N-acetylglucosaminyltransferase manic fringe; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Show all	Predicted intracellular proteins Show all	GO:0016020 [membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	43 aa 5 kDa	No	0
MFNG-005 ENSP00000394081 ENST00000436341	A9UJQ1 [Direct mapping] Beta-1,3-N-acetylglucosaminyltransferase manic fringe; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	132 aa 14.9 kDa	No	0
MFNG-007 ENSP00000407110 ENST00000424765	A9UJP9 [Direct mapping] Beta-1,3-N-acetylglucosaminyltransferase manic fringe; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	118 aa 13.2 kDa	Yes	0
MFNG-010 ENSP00000407094 ENST00000454291	H0Y6Q9 [Direct mapping] Beta-1,3-N-acetylglucosaminyltransferase manic fringe Show all	Predicted intracellular proteins Show all		87 aa 9.2 kDa	No	0
MFNG-201 ENSP00000413855 ENST00000416983	O00587 [Direct mapping] Beta-1,3-N-acetylglucosaminyltransferase manic fringe Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0002315 [marginal zone B cell differentiation] GO:0005615 [extracellular space] GO:0007389 [pattern specification process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030173 [integral component of Golgi membrane] GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	307 aa 34.7 kDa	Yes	0