Cell atlas - CARD10 - The Human Protein Atlas

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CARD10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Intermediate filaments
	Vesicles

Human cell
	Cytosol
	Intermediate Filaments
	Vesicles

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GENERAL INFORMATION
Gene name	CARD10
Gene description	Caspase recruitment domain family, member 10
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the intermediate filaments & vesicles. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Intermediate filaments (approved)
Additional location	In addition localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055612
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the intermediate filaments & vesicles. In addition localized to the cytosol.

Main location

Vesicles (approved), Intermediate filaments (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055612	A-431	Intermediate filaments
	HPA055612	A-431	Cytosol
	HPA055612	HeLa	Vesicles
	HPA055612	U-2 OS	Vesicles
	HPA055612	U-2 OS	Intermediate filaments	Intensity

GENE INFORMATION
Gene name	CARD10 (HGNC Symbol)
Synonyms	BIMP1, CARMA3
Description	Caspase recruitment domain family, member 10 (HGNC Symbol)
Entrez gene summary	The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37490362 - 37519542
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100065 (version 83.38)
Entrez gene	29775
UniProt	Q9BWT7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BWT7
Antibodypedia	CARD10 antibodies

PROTEIN BROWSER

CARD10-001	CARD10-002	CARD10-003	CARD10-005	CARD10-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARD10-001 ENSP00000384570 ENST00000403299	Q9BWT7 [Direct mapping] Caspase recruitment domain-containing protein 10 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006461 [protein complex assembly] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0030159 [receptor signaling complex scaffold activity] GO:0032449 [CBM complex] GO:0042981 [regulation of apoptotic process] Show all	1032 aa 115.9 kDa	No	0
CARD10-002 ENSP00000251973 ENST00000251973	Q9BWT7 [Direct mapping] Caspase recruitment domain-containing protein 10 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006461 [protein complex assembly] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0030159 [receptor signaling complex scaffold activity] GO:0032449 [CBM complex] GO:0042981 [regulation of apoptotic process] Show all	1032 aa 115.9 kDa	No	0
CARD10-003 ENSP00000385799 ENST00000406271	Q9BWT7 [Direct mapping] Caspase recruitment domain-containing protein 10 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006461 [protein complex assembly] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0030159 [receptor signaling complex scaffold activity] GO:0032449 [CBM complex] GO:0042981 [regulation of apoptotic process] Show all	746 aa 82.5 kDa	No	0
CARD10-005 ENSP00000416239 ENST00000437756	B0QYC4 [Direct mapping] Caspase recruitment domain-containing protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		480 aa 53.1 kDa	No	0
CARD10-006 ENSP00000393411 ENST00000433485	B0QYC3 [Direct mapping] Caspase recruitment domain-containing protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 20.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.