We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear and/or membranous positivity in several tissues. Several cases of malignant carcinoids along with a few melanomas, lymphomas, ovarian, thyroid and urothelial cancers were strongly positive. Most cases of renal, liver and lung cancers were negative.
Most of the cancer tissues showed weak to moderate cytoplasmic positivity with additional membranous staining in several cases. Many gliomas and renal cancers were negative.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]