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Cancer tissues displayed moderate to strong nuclear staining with additional cytoplasmic positivity in few tissues. Several cases of renal cancers were weakly stained or negative.
Cancer tissues displayed weak to moderate cytoplasmic and/or nuclear staining. Occasional cases of melanomas, thyroid, breast and urothelial cancers were strongly stained. Several cases of stomach, endometrial and colorectal cancers were negative.
GENE INFORMATION
Gene name
PATZ1 (HGNC Symbol)
Synonyms
dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG
Description
POZ (BTB) and AT hook containing zinc finger 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Q9HBE1 [Direct mapping] POZ-, AT hook-, and zinc finger-containing protein 1 A0A024R1M5 [Target identity:100%; Query identity:100%] Zinc finger protein 278, isoform CRA_c
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007283 [spermatogenesis] GO:0008584 [male gonad development] GO:0010468 [regulation of gene expression] GO:0030217 [T cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
Q9HBE1 [Direct mapping] POZ-, AT hook-, and zinc finger-containing protein 1 A0A024R1H7 [Target identity:100%; Query identity:100%] Zinc finger protein 278, isoform CRA_b
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q9HBE1 [Direct mapping] POZ-, AT hook-, and zinc finger-containing protein 1
Show all
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q9HBE1 [Direct mapping] POZ-, AT hook-, and zinc finger-containing protein 1 A0A024R1F8 [Target identity:100%; Query identity:100%] Zinc finger protein 278, isoform CRA_d
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
