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A few cases of liver cancers showed strong membranous positivity. Weak to moderate staining was observed in several renal, endometrial and prostate cancers. Remaining cancers were mainly negative.
Several renal, prostate and endometrial cancers showed moderate membranous positivity. A few cases of liver and pancreatic cancers showed strong immunoreactivity. Remaining cancer tissues were in general negative.
This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013]