Cell atlas - SLC16A8 - The Human Protein Atlas

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SLC16A8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Focal adhesion sites
	Intermediate filaments

Human cell
	Actin Filaments
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	SLC16A8
Gene description	Solute carrier family 16 (monocarboxylate transporter), member 8
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the focal adhesion sites. In addition localized to the intermediate filaments.
RNA cell category	Cell line enhanced (U-266/70, T-47d, SiHa)
Protein evidence	Evidence at transcript level
Main location	Localized to the Focal adhesion sites (approved)
Additional location	In addition localized to the Intermediate filaments (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA075017
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, T-47d, SiHa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the focal adhesion sites. In addition localized to the intermediate filaments.

Main location

Focal adhesion sites (approved)

Additional location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075017	RT4	No staining
	HPA075017	SiHa	Focal adhesion sites
	HPA075017	U-2 OS	Intermediate filaments	Intensity
	HPA075017	U-2 OS	Focal adhesion sites

GENE INFORMATION
Gene name	SLC16A8 (HGNC Symbol)
Synonyms	MCT3, REMP
Description	Solute carrier family 16 (monocarboxylate transporter), member 8 (HGNC Symbol)
Entrez gene summary	SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	38078134 - 38084093
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000100156 (version 83.38)
Entrez gene	23539
UniProt	O95907 (UniProt - Evidence at transcript level)
neXtProt	NX_O95907
Antibodypedia	SLC16A8 antibodies

PROTEIN BROWSER

SLC16A8-001	SLC16A8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A8-001 ENSP00000321735 ENST00000320521	O95907 [Direct mapping] Monocarboxylate transporter 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0009925 [basal plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0015727 [lactate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	504 aa 52.3 kDa	No	>9
SLC16A8-003 ENSP00000409547 ENST00000427592	B0QYL4 [Direct mapping] Monocarboxylate transporter 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0035879 [plasma membrane lactate transport] Show all	97 aa 10.1 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.