Cell atlas - CENPM - The Human Protein Atlas

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CENPM

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CENPM
Gene description	Centromere protein M
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA042404 , HPA056500
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA042404	HEK 293	No staining
HPA042404	MCF7	No staining
HPA042404	U-2 OS	Cytosol
HPA056500	HeLa	Cytosol
HPA056500	MCF7	No staining
HPA056500	U-2 OS	Cytosol

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000068101 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA042404	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CENPM (HGNC Symbol)
Synonyms	C22orf18, CENP-M, MGC861, Pane1
Description	Centromere protein M (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	41938721 - 41947164
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100162 (version 83.38)
Entrez gene	79019
UniProt	Q9NSP4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NSP4
Antibodypedia	CENPM antibodies

PROTEIN BROWSER

CENPM-001	CENPM-002	CENPM-003	CENPM-004	CENPM-005	CENPM-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CENPM-001 ENSP00000215980 ENST00000215980	Q9NSP4 [Direct mapping] Centromere protein M A0A024R1Q3 [Target identity:100%; Query identity:100%] Chromosome 22 open reading frame 18, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] Show all	180 aa 19.7 kDa	No	0
CENPM-002 ENSP00000384132 ENST00000402420	B1AHQ8 [Direct mapping] Centromere protein M Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.8 kDa	No	0
CENPM-003 ENSP00000430624 ENST00000472374	Q9NSP4 [Direct mapping] Centromere protein M Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] Show all	58 aa 6.3 kDa	No	0
CENPM-004 ENSP00000384731 ENST00000402338	B1AHQ6 [Direct mapping] Centromere protein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16.1 kDa	No	0
CENPM-005 ENSP00000384814 ENST00000404067	B1AHQ7 [Direct mapping] Centromere protein M Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.1 kDa	No	0
CENPM-008 ENSP00000384743 ENST00000407253	Q9NSP4 [Direct mapping] Centromere protein M Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] Show all	107 aa 11.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.