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XBP1

GENERAL INFORMATION

Gene name

 XBP1

Gene description

 X-box binding protein 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 XBP1 (HGNC Symbol)

Synonyms

 XBP2

Description

 X-box binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.1

Chromosome location (bp)

 28794555 - 28800597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100219 (version 83.38)

Entrez gene

 7494

UniProt

 P17861 (UniProt - Evidence at protein level)

neXtProt

 NX_P17861

Antibodypedia

 XBP1 antibodies

PROTEIN BROWSER
XBP1-001
XBP1-003
XBP1-006
XBP1-007
XBP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XBP1-001
ENSP00000216037
ENST00000216037
P17861 [Direct mapping]
X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
A0A024R1F0 [Target identity:100%; Query identity:100%]
X-box binding protein 1, isoform CRA_b
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002020 [protease binding]
GO:0002070 [epithelial cell maturation]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006914 [autophagy]
GO:0006955 [immune response]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0006996 [organelle organization]
GO:0007517 [muscle organ development]
GO:0010506 [regulation of autophagy]
GO:0010508 [positive regulation of autophagy]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016049 [cell growth]
GO:0019901 [protein kinase binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030331 [estrogen receptor binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031017 [exocrine pancreas development]
GO:0031062 [positive regulation of histone methylation]
GO:0031490 [chromatin DNA binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031648 [protein destabilization]
GO:0031670 [cellular response to nutrient]
GO:0032008 [positive regulation of TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0034599 [cellular response to oxidative stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042593 [glucose homeostasis]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048666 [neuron development]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0055089 [fatty acid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060612 [adipose tissue development]
GO:0060691 [epithelial cell maturation involved in salivary gland development]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071332 [cellular response to fructose stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1900100 [positive regulation of plasma cell differentiation]
GO:1900102 [negative regulation of endoplasmic reticulum unfolded protein response]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1900413 [positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1901985 [positive regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903489 [positive regulation of lactation]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 261 aa
28.7 kDa 		No 0
XBP1-003
ENSP00000384295
ENST00000405219
B1AHH1 [Direct mapping]
X-box-binding protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 211 aa
24 kDa 		No 1
XBP1-006
ENSP00000385162
ENST00000403532
B1AHH2 [Direct mapping]
X-box-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 266 aa
29.3 kDa 		No 0
XBP1-007
ENSP00000343155
ENST00000344347
P17861 [Direct mapping]
X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002020 [protease binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006914 [autophagy]
GO:0006955 [immune response]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0006996 [organelle organization]
GO:0007517 [muscle organ development]
GO:0010508 [positive regulation of autophagy]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016049 [cell growth]
GO:0019901 [protein kinase binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030331 [estrogen receptor binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031062 [positive regulation of histone methylation]
GO:0031490 [chromatin DNA binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031648 [protein destabilization]
GO:0031670 [cellular response to nutrient]
GO:0032008 [positive regulation of TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0034599 [cellular response to oxidative stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048666 [neuron development]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0055089 [fatty acid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060612 [adipose tissue development]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071332 [cellular response to fructose stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1900100 [positive regulation of plasma cell differentiation]
GO:1900102 [negative regulation of endoplasmic reticulum unfolded protein response]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1900413 [positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter]
GO:1901985 [positive regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903489 [positive regulation of lactation]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 376 aa
40.1 kDa 		No 0
XBP1-201
ENSP00000481170
ENST00000611155
P17861 [Direct mapping]
X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002020 [protease binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006914 [autophagy]
GO:0006955 [immune response]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0006996 [organelle organization]
GO:0007517 [muscle organ development]
GO:0010508 [positive regulation of autophagy]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016049 [cell growth]
GO:0019901 [protein kinase binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030331 [estrogen receptor binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031062 [positive regulation of histone methylation]
GO:0031490 [chromatin DNA binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031648 [protein destabilization]
GO:0031670 [cellular response to nutrient]
GO:0032008 [positive regulation of TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0034599 [cellular response to oxidative stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048666 [neuron development]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0055089 [fatty acid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060612 [adipose tissue development]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071332 [cellular response to fructose stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1900100 [positive regulation of plasma cell differentiation]
GO:1900102 [negative regulation of endoplasmic reticulum unfolded protein response]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1900413 [positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter]
GO:1901985 [positive regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903489 [positive regulation of lactation]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 376 aa
40.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.