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CYB5R3

CANCER ATLAS

Gene description

 Cytochrome b5 reductase 3

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001566

GENE INFORMATION

Gene name

 CYB5R3 (HGNC Symbol)

Synonyms

 DIA1

Description

 Cytochrome b5 reductase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 42617840 - 42649568

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100243 (version 83.38)

Entrez gene

 1727

UniProt

 P00387 (UniProt - Evidence at protein level)

neXtProt

 NX_P00387

Antibodypedia

 CYB5R3 antibodies

PROTEIN BROWSER
CYB5R3-001
CYB5R3-002
CYB5R3-003
CYB5R3-006
CYB5R3-007
CYB5R3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYB5R3-001
ENSP00000338461
ENST00000352397
P00387 [Direct mapping]
NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005833 [hemoglobin complex]
GO:0006695 [cholesterol biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071949 [FAD binding]
Show all
 301 aa
34.2 kDa 		No 1
CYB5R3-002
ENSP00000384834
ENST00000407623
P00387 [Direct mapping]
NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005833 [hemoglobin complex]
GO:0006695 [cholesterol biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071949 [FAD binding]
Show all
 278 aa
31.6 kDa 		No 0
CYB5R3-003
ENSP00000384457
ENST00000407332
P00387 [Direct mapping]
NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005833 [hemoglobin complex]
GO:0006695 [cholesterol biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071949 [FAD binding]
Show all
 278 aa
31.6 kDa 		No 0
CYB5R3-006
ENSP00000403439
ENST00000438270
B1AHF3 [Direct mapping]
NADH-cytochrome b5 reductase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 147 aa
16.7 kDa 		No 0
CYB5R3-007
ENSP00000385679
ENST00000402438
P00387 [Direct mapping]
NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005833 [hemoglobin complex]
GO:0006695 [cholesterol biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071949 [FAD binding]
Show all
 278 aa
31.6 kDa 		No 0
CYB5R3-201
ENSP00000354468
ENST00000361740
P00387 [Direct mapping]
NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005833 [hemoglobin complex]
GO:0006695 [cholesterol biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0016208 [AMP binding]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0043531 [ADP binding]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071949 [FAD binding]
Show all
 334 aa
38.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.