Expression of HMGXB4 in cancer - Summary

CANCER ATLAS

Gene description

HMG box domain containing 4

Protein class

Cancer-related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000725

GENE INFORMATION
Gene name	HMGXB4 (HGNC Symbol)
Synonyms	HMG2L1, THC211630
Description	HMG box domain containing 4 (HGNC Symbol)
Entrez gene summary	High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	35257452 - 35295807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100281 (version 83.38)
Entrez gene	10042
UniProt	Q9UGU5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGU5
Antibodypedia	HMGXB4 antibodies

PROTEIN BROWSER

HMGXB4-002	HMGXB4-003	HMGXB4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMGXB4-002 ENSP00000216106 ENST00000216106	Q9UGU5 [Direct mapping] HMG domain-containing protein 4 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0008333 [endosome to lysosome transport] GO:0016055 [Wnt signaling pathway] GO:0016589 [NURF complex] GO:0030178 [negative regulation of Wnt signaling pathway] Show all	601 aa 65.7 kDa	No	0
HMGXB4-003 ENSP00000415500 ENST00000455359	B0QXZ8 [Direct mapping] HMG domain-containing protein 4 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	284 aa 30.4 kDa	No	0
HMGXB4-004 ENSP00000401658 ENST00000420166	B0QXZ9 [Direct mapping] HMG domain-containing protein 4 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	285 aa 30.5 kDa	No	0