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TOM1

CANCER ATLAS

Gene description

 Target of myb1 membrane trafficking protein

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001749

GENE INFORMATION

Gene name

 TOM1

Synonyms

Description

 Target of myb1 membrane trafficking protein (HGNC Symbol)

Entrez gene summary

 This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 35299275 - 35347994

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100284 (version 83.38)

Entrez gene

 10043

UniProt

 O60784 (UniProt - Evidence at protein level)

neXtProt

 NX_O60784

Antibodypedia

 TOM1 antibodies

PROTEIN BROWSER
TOM1-001
TOM1-008
TOM1-012
TOM1-016
TOM1-017
TOM1-201
TOM1-202
TOM1-203
TOM1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOM1-001
ENSP00000394466
ENST00000449058
O60784 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016197 [endosomal transport]
GO:0030276 [clathrin binding]
GO:0070062 [extracellular exosome]
Show all
 492 aa
53.8 kDa 		No 0
TOM1-008
ENSP00000393714
ENST00000456128
B0QY01 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 335 aa
37 kDa 		No 0
TOM1-012
ENSP00000389789
ENST00000443206
B0QY02 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 151 aa
16.9 kDa 		No 0
TOM1-016
ENSP00000476698
ENST00000608749
V9GYF4 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 134 aa
15.2 kDa 		No 0
TOM1-017
ENSP00000477471
ENST00000608674
V9GZ68 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 125 aa
14.2 kDa 		No 0
TOM1-201
ENSP00000371465
ENST00000382034
Q6UW50 [Direct mapping]
TOM1; Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 209 aa
23.5 kDa 		No 0
TOM1-202
ENSP00000413697
ENST00000411850
O60784 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016197 [endosomal transport]
GO:0030276 [clathrin binding]
GO:0070062 [extracellular exosome]
Show all
 493 aa
53.9 kDa 		No 0
TOM1-203
ENSP00000394924
ENST00000425375
O60784 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016197 [endosomal transport]
GO:0030276 [clathrin binding]
GO:0070062 [extracellular exosome]
Show all
 447 aa
48.7 kDa 		No 0
TOM1-204
ENSP00000398876
ENST00000447733
O60784 [Direct mapping]
Target of Myb protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016197 [endosomal transport]
GO:0030276 [clathrin binding]
GO:0070062 [extracellular exosome]
Show all
 460 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.